Teratogenicity study in rats of commonly used calcium channel blockers
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منابع مشابه
Effect of Some Calcium Channel Blockers in Experimentally Induced Diabetic Nephropathy in Rats
Diabetic nephropathy (DNP) is considered a CRD (Chronic Renal Disease); it is a major cause of illness and premature death in people with DM. The present study was designed to illustrate the role of CCBs (amlodipine and diltiazem) in prevention and treatment of DNP in rats. Eighty male albino rats weighing (130-180gm) were used in this study. These animals were subdivided into five equal groups...
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Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory...
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The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کامل61: Calcium Channel Blockers
In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, ...
متن کاملCalcium Channel Blockers
The agents commonly called the calcium channel blockers comprise an increasing number of agents, including the prototypical verapamil (Calan, Isoptin), nifedipine (Adalat, Procardia), and diltiazem (Cardizem). These agents are a chemically and pharmacologically heterogeneous group of synthetic drugs, but they possess the common property of selectively antagonizing Ca movements that underlie the...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2019
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20195282